Preheat oven to 450 degrees F. Grease a large baking sheet and set it aside.
Place broccoli florets into a bowl and drizzle with olive oil. Stir until evenly coated. Sprinkle with salt and pepper to taste.
Spread seasoned broccoli evenly on the baking sheet and roast at 450 degrees F for 10-15 minutes, stirring once halfway through. Remove from the oven once broccoli is nicely roasted.
While the broccoli is roasting, begin preparing your catfish.
In a small bowl, combine garlic powder, onion powder, dried oregano, paprika, red pepper, ground black pepper and salt. Coat both sides of the catfish with seasoning mix.
In a large skillet, add 1 tablespoon of olive oil over high heat. Add 2 Heartland Catfish fillets to skillet and cook for 2 to 4 minutes per side or until the fish easily flakes with a fork.
Repeat with remaining tablespoon of olive oil and other 2 catfish fillets. Serve immediately with roasted broccoli.